Shorter prophylactic antibiotics are feasible after clean orthopedic surgery


MONDAY, April 12, 2022 (HealthDay News) — According to a study published online April 12 in Open JAMA Network.

Kosei Nagata, Ph.D., of Tokyo University Hospital, and colleagues examined whether shorter duration of antimicrobial prophylaxis (

The researchers found that healthcare-associated infections occurred in 4.6% of patients arrested within 24 hours and 6.6% of those arrested within 48 hours. A risk difference of −1.99 percentage points (95% confidence interval, −5.05 to 1.06 percentage points; P

“These results provide support for the global movement against antimicrobial resistance and provide additional insight into adequate antimicrobial prophylaxis for clean orthopedic surgery,” the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

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